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Endocrine Disorders Growth Hormone

Growth Hormone: Keeping Levels Steady


Author:

Shlomo Melmed, MD

Cedars-Sinai Health System

Medically Reviewed On: September 27, 2002

Growth hormone is one of the most essential chemicals in the human body. Produced in the pituitary gland at the base of the brain, growth hormone is responsible for growth during childhood and adolescence, and also helps to regulate the body's fat and muscle throughout life. Too much or too little growth hormone results in different problems across the age span.

Below, Dr. Shlomo Melmed of Cedars-Sinai Health System talks about the role of growth hormone in the body and what can be done to set the level right again.

What does growth hormone do?
Growth hormone stimulates the bones and other organs to grow. It also regulates how cells utilize glucose and fat, and stimulates the liver to manufacture another hormone, called "insulin-like growth factor 1" or IGF1. IGF1 has a number of functions, and one is to stimulate bone growth.

What happens in the body when it doesn't have enough growth hormone?
If the deficiency occurs during infancy, childhood or adolescence, then that individual will not grow to the height at which he or she would have grown under normal circumstances. If, however, growth hormone deficiency occurs after the individual has completed his or her growth, then that individual will usually present with obesity, fat around the abdominal area, high lipid levels in the blood, low energy, decreased muscle mass and a general feeling of depression and isolation.

What happens if the body produces too much growth hormone?
If there is excess growth hormone prior to the end of the normal growth phase, then the individual will, in fact, continue to grow. So individuals who are seven feet tall or taller may have had excess growth hormone during their growth phase, which resulted in their long bones continuing to grow.

If there is excess growth hormone after the growth phase has ended, then bony overgrowth in the face, jaws, and skulls can occur. For example, patients will complain of increasing ring size or increasing shoe size, due to growth of those bones in the feet or in the fingers or, in fact, due to accumulation of water in the soft tissues. These are features of a condition we call "acromegaly," where there is generalized body overgrowth rather than increase in height.

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